
Giants vs Athletics Prediction 5/16/25 MLB Picks Today
Oakland Athletics (22-22) vs. San Francisco Giants (25-19)
May 16, 2025 10:15 pm EDT
The Line: San Francisco Giants -180 / Oakland Athletics 150; Over/Under: 7
(Get latest betting odds)
In this article, we will formulate a Giants vs Athletics prediction for this MLB game on Friday, May 16, at Oracle Park in San Francisco, California. Let’s take a look at the prediction for this MLB matchup.
Athletics Betting Preview
The Athletics (22-22, 14-9 Away) lost six of the previous eight games, losing the series to the Mariners, Yankees, and Dodgers in the process. The A’s did beat the Dodgers in Game 1 of the series in Los Angeles, but then lost the following two, including a massive 19-2 loss on Thursday, their biggest of the season. Osvaldo Bido took the loss after allowing six runs on five hits with two strikeouts and two walks in 1.2 innings.
This year, the Athletics average 4.45 runs per game (14th in the MLB) on a .258/.317/.428 triple-slash. When it comes to pitching, the Athletics’ staff has a 5.18 ERA (26th) and 1.50 WHIP (28th). Tyler Soderstrom leads the Athletics with a .280 batting average, ten home runs, and 29 RBI this season.
The projected starting pitcher for the Athletics is JP Sears, who is 4-2 in eight starts this season, with a 2.80 ERA and 1.00 WHIP in 45.0 innings.
San Francisco Giants Betting Preview
The San Francisco Giants (25-19, 13-7 Home) beat the Chicago Cubs and then lost the series to the Twins and Diamondbacks. The Giants were swept by Minnesota on the road before losing to Arizona at home. In the most recent 8-7 defeat, Heliot Ramos led the team with three RBI, while Jordan Hicks took the loss after allowing five runs on seven hits with one strikeout and one walk in 2.0 innings.
This season, the Giants average 4.75 runs per game (9th in the MLB) on a .237/.312/.386 triple-slash. When it comes to pitching, the Giants’ staff has a 3.56 ERA (8th) and 1.25 WHIP (14th). Wilmer Flores leads the Giants with a .255 batting average, seven home runs, and 33 RBI this season.
Logan Webb will take the mound for the Giants on Friday. The 28-year-old right-hander has a 4-3 record in nine starts this year with a 2.60 ERA and 1.16 WHIP in 55.1 innings.
Total Runs Facts
- Each of the Athletics’ last eight night games against NL West opponents have gone OVER the total runs line.
- Eight of the Giants’ last nine games as favorites against American League opponents have gone UNDER the total runs line.
- The ‘Inning 1 UNDER 0.5 runs’ market has hit in 11 of the Giants’ last 13 night games against AL West opponents.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Athletics’ last six games as underdogs against NL West opponents.
Matchup/League Facts
- The Giants rank T23rd in the league for steals this season (25).
- The Giants rank T23rd in the league for strikeouts against this season (381).
- The Athletics rank 29th in the league for runs allowed this season (247).
- The Athletics rank T28th in the league for steals this season (19).
Giants vs Athletics Prediction
The Giants won six of the previous ten H2H encounters, but the Athletics were better in four of the last six. Eight of the A’s last ten games went Over, which was the case in six of San Francisco’s previous ten. Sears and Webb are the best starters these respective teams have at the moment, but I am going with Over because of a relatively low total. I am backing the teams to score at least two runs each in the opening five innings, and later, the bullpens will take care of us and our winning bet. Especially the Athletics’, which is one of the worst in the MLB.