Cubs vs White Sox Prediction 5/16/25 MLB Picks Today

The Chicago White Sox and Chicago Cubs meet Friday in MLB action at Wrigley Field. Here’s a Cubs vs White Sox Prediction. This article will include a Cubs vs White Sox Pick.

Chicago White Sox Betting Preview

The Chicago White Sox are 14-30 on the year and play the Mariners, Rangers, and Mets next. The Chicago White Sox are batting .214 on the season, have a .289 OBP, and a .324 slugging percentage. The Chicago White Sox pitching staff has a 4.04 ERA and a 1.37 WHIP. Lenyn Sosa leads the Chicago White Sox with 40 hits and 11 RBI, while Miguel Vargas and Andrew Vaughn have combined for 64 hits and 34 RBI.

Shane Smith gets the ball for the Chicago White Sox, and he is 1-2 with a 2.08 ERA and 38 strikeouts this season. This will be Smith’s first career game against the Chicago Cubs.

Chicago Cubs Betting Preview

The Chicago Cubs are 25-19 on the year and play the Marlins, Reds, and Rockies next. The Chicago Cubs are batting .250 on the season, have a .327 OBP, and a .436 slugging percentage. The Chicago Cubs pitching staff has a 4.02 ERA and a 1.30 WHIP. Pete Crow-Armstrong leads the Chicago Cubs with 45 hits and 30 RBI, while Kyle Tucker and Ian Happ have combined for 88 hits and 52 RBI.

Cade Horton gets the ball for the Chicago Cubs, and he is 1-0 with a 6.75 ERA and 5 strikeouts this season. This will be Horton’s first career game against the Chicago White Sox.

Why the Chicago Cubs will win

• The Cubs have won each of their last six home games against AL Central opponents following a home loss.
• The White Sox have lost 12 of their last 13 games against NL Central opponents following a loss.
• The Cubs have covered the run line in each of their last four day games against AL Central opponents following a loss.
• The White Sox have failed to cover the run line in four of their last five day games against NL Central opponents.
• The Cubs have led after 5 innings in each of their last six day games against AL Central opponents that held a losing record.
• The Cubs have led after 3 innings in each of their last four day games against AL Central opponents that held a losing record.

Why the Chicago White Sox will win

• The White Sox have won five of their last six games as underdogs against National League opponents.
• The White Sox have covered the run line in each of their last six road games against the Cubs following a loss.
• The Cubs have failed to cover the run line in eight of their last nine home games against the White Sox following a loss.
• The Cubs have trailed after 3 innings in three of their last four day games.
• The White Sox have led after 5 innings in eight of their last 10 games against the Cubs at Wrigley Field.

Chicago Cubs Player Prop Facts

• Seiya Suzuki has hit at least one home run in three of the Cubs’ last four day games against opponents that held a losing record.
• Seiya Suzuki has scored at least one run in each of the Cubs’ last six games against AL opponents.
• Seiya Suzuki has recorded at least one RBI in each of the Cubs’ last seven games against AL opponents.
• Seiya Suzuki has recorded at least one hit in each of the Cubs’ last 10 games as favorites against AL opponents.
• Seiya Suzuki has recorded at least one Single in each of the Cubs’ last 10 games as favorites against AL opponents.
• Pete Crow-Armstrong ranks T5th in the league in Steals (13) this season.

Chicago White Sox Player Prop Facts

• Miguel Vargas has hit a home run in five of his last six appearances against NL Central opponents that held a winning record.
• Luis Robert has recorded at least one hit in each of his last 10 appearances against NL Central opponents that held a winning record.
• Luis Robert has recorded a Single in each of his last six appearances against NL Central opponents that held a winning record.
• Andrew Benintendi has scored a run in each of his last five appearances.
• Miguel Vargas has recorded at least one RBI in five of his last six appearances against NL Central opponents that held a winning record.
• Andrew Benintendi has recorded a Double in each of his five previous appearances at Wrigley Field.
• Luis Robert ranks 1st in the league in Steals (17) this season.

Cubs vs White Sox Prediction

The White Sox have won four of their last six games, but they’re not a team I’m eager to back. Those few wins don’t move the needle. The White Sox were the worst team in baseball the last two years and are 16 games below a .500 record this season. A $100 bettor is down more than $2,400 this season, backing the White Sox all season. There’s zero betting value with the White Sox, and it’s just that simple. Horton wasn’t good in his season debut, allowing four hits and three runs in four innings against the Mets. Who cares. The White Sox stink. Give me the Cubs and the RL for max betting value.