Cardinals vs Tigers Prediction 5/21/25 MLB Picks Today

The Detroit Tigers and the St. Louis Cardinals meet Wednesday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cardinals vs Tigers Prediction.

Starting Pitching Matchup

The Detroit Tigers did not have a starting pitcher announced at the time that this article was posted. Andre Pallante will get the start for the Cardinals here and is 4-2 with a 4.11 ERA and 32 strikeouts this season. This will be Pallante’s first career start against the Tigers.

Detroit Tigers Recap

The Detroit Tigers come into this game looking to build on their 5-4 win over the Cardinals from Tuesday’s matchup to improve to 32-17 this season. After this series, the Tigers will head home for a series against the division rival Guardians.

Tigers Looking For Some Consistency

Spencer Torkelson has 41 hits along with a .240 batting average, including a team-high 12 home runs, 12 doubles, and 38 RBIs. Kerry Carpenter also has 10 home runs and 22 RBIs, while Riley Greene has 53 hits with 10 doubles, 12 home runs, and 34 RBIs, but also has a team-high 57 strikeouts this season. Dillon Dingler has 4 home runs and 17 RBIs, and Zack McKinstry’s added 9 doubles, 3 triples, 2 home runs, and 17 RBIs of his own along with 44 hits this season. Javier Baez had added 39 hits and 8 doubles as well as 6 home runs and 28 RBIs this season.

Why the Detroit Tigers will win

• The Cardinals have lost six of their last eight games as favorites against AL Central opponents.
• The Tigers have won seven of their last 10 games as underdogs against the Cardinals.
• The Tigers have covered the run line each of their last 12 Wednesday games against teams that held a winning record.
• The Cardinals have failed to cover the run line in seven of their last eight games as favorites against AL Central opponents.

Detroit Tigers Player Prop Facts

• Riley Greene has hit a home run in three of the Tigers’ last five games against the Cardinals.
• Spencer Torkelson has recorded at least one RBI in each of the Tigers’ last five day games.
• Zach McKinstry has recorded at least one Single in each of his last 12 appearances against opponents that held a winning record.
• Zach McKinstry has recorded at least one hit in each of his last 12 appearances against opponents that held a winning record.
• Matt Vierling has recorded a Double in five of his last six appearances in day games against NL teams that held a winning record.
• Parker Meadows has scored at least one run in each of his last four appearances against NL Central opponents that held a winning record.
• Riley Greene ranks T8th in the league in Home Runs (12) this season.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to bounce back from their loss at the hands of the Tigers on Tuesday to slip to 27-22 on the year. After this series, the Cardinals will welcome the Arizona Diamondbacks to town for a matchup.

Cardinals Alternate Wins & Losses In Four Straight

Brendan Donovan has a team-high 61 hits along with 16 doubles, 3 home runs, and 22 RBIs, while Lars Nootbaar has 48 hits with 7 home runs, 25 RBIs, and 4 stolen bases. Nolan Arenado also has 43 hits with 10 doubles, 5 home runs, and 21 RBIs of his own, and Victor Scott II has 40 hits with 8 doubles, a triple, 8 RBIs, and a team-high 13 stolen bases. Willson Contreras has also chipped in 45 hits with 6 home runs and 27 RBIs of his own this season.

Why the St. Louis Cardinals will win

• The Cardinals have won each of their last eight day games at Busch Stadium following a home loss.
• The Tigers have lost each of their last four games against NL Central opponents following a win.
• The Cardinals have covered the run line in 15 of their last 16 games.
• The Tigers have failed to cover the run line in each of their last seven games following a win.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has hit a home run in three of his last six appearances against opponents that held a winning record.
• Brendan Donovan has recorded a Double in each of the Cardinals’ last four games as favorites.
• Nolan Arenado has recorded at least one RBI in each of the Cardinals’ last six home games against AL opponents that held a winning record.
• Masyn Winn has scored at least one run in each of his last six home appearances against opponents that held a winning record.
• Nolan Arenado has recorded at least one Single in each of the Cardinals’ last nine day games against AL opponents that held a winning record.
• Brendan Donovan has recorded at least one hit in each of the Cardinals’ last 11 games as favorites.
• Brendan Donovan ranks 3rd in the league in Hits (61) this season.

Total Runs Facts

• Each of the Tigers’ last five games against National League opponents have gone OVER the total runs line.
• Each of the last five games between the Tigers and Cardinals at Busch Stadium have gone OVER the total runs line.

Cardinals vs Tigers Prediction

I’m on the Tigers here. I get the case to be made for the Cardinals, who have been one of the hottest teams in baseball this season, but the thing is that the Tigers continue to hit really well against right-handed pitching. Furthermore, I’m just not buying into Andre Pallante, and I think the Tigers get the job done in this one to pick up another series win. Still crazy that the Tigers have the best record in baseball, but here we are. Give me Detroit.