Blue Jays vs Padres Prediction 5/21/25 MLB Picks Today

The San Diego Padres and Toronto Blue Jays meet Wednesday in MLB action at Rogers Centre. Here’s a Blue Jays vs Padres Prediction. This article will include a Blue Jays vs Padres Pick.

San Diego Padres Betting Preview

The San Diego Padres are 27-19 on the year and play the Braves, Marlins, and Pirates next. The San Diego Padres are batting .259 on the season, have a .326 OBP, and a .392 slugging percentage. The San Diego Padres pitching staff has a 3.39 ERA and a 1.16 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 53 hits and 27 RBI, while Manny Machado and Luis Arraez have combined for 100 hits and 35 RBI.

Randy Vasquez gets the ball for the San Diego Padres, and he is 3-3 with a 3.45 ERA and 23 strikeouts this season. This will be Vasquez’s second career game against the Toronto Blue Jays.

Toronto Blue Jays Betting Preview

The Toronto Blue Jays are 23-24 on the year and play the Rays, Rangers, and Athletics next. The Toronto Blue Jays are batting .247 on the season, have a .316 OBP, and a .379 slugging percentage. The Toronto Blue Jays’ pitching staff has a 4.21 ERA and a 1.23 WHIP. Bo Bichette leads the Toronto Blue Jays with 57 hits and 22 RBI, while Vladimir Guerrero Jr. and Alejandro Kirk have combined for 89 hits and 39 RBI.

Kevin Gausman gets the ball for the Toronto Blue Jays, and he is 3-4 with a 4.59 ERA and 46 strikeouts this season. Gausman is 2-1 with a 3.35 ERA and 43 strikeouts in his career against the San Diego Padres.

Why the Toronto Blue Jays will win

Why the San Diego Padres will win

Toronto Blue Jays Player Prop Facts

San Diego Padres Player Prop Facts

Blue Jays vs Padres Prediction

The Blue Jays are getting love at home with Gausman on the mound, but he’s allowed 17 hits and nine runs in his last 11 innings. Gausman has allowed 19 runs in his last 19.2 innings. Vasquez has been more reliable this season, and that includes giving up 16 hits and four runs in his last 17 innings. The Padres are 3-0 with Vasquez on the mound this month. Also, it’s only a matter of time before the Padres wake up offensively, as this lineup is too talented to score just three runs in their last four games. The market is starting to shift on the Padres. I’ll take a shot with them in a bounce-back spot.

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