Marlins vs Cubs Prediction 5/21/25 MLB Picks Today

The Chicago Cubs and Miami Marlins meet Wednesday in MLB action at loanDepot park. Here’s a Marlins vs Cubs Prediction. This article will include a Marlins vs Cubs Pick.

Chicago Cubs Betting Preview

The Chicago Cubs are 29-20 on the year and play the Reds, Rockies, and Reds next. The Chicago Cubs are batting .261 on the season, have a .336 OBP, and a .448 slugging percentage. The Chicago Cubs pitching staff has a 3.96 ERA and a 1.28 WHIP. Pete Crow-Armstrong leads the Chicago Cubs with 22 hits and 39 RBI, while Nico Hoerner and Kyle Tucker have combined for 103 hits and 56 RBI.

Cade Horton gets the ball for the Chicago Cubs, and he is 2-0 with a 6.00 ERA and 7 strikeouts this season. This will be Horton’s first career game against the Miami Marlins.

Miami Marlins Betting Preview

The Miami Marlins are 19-28 on the year and play the Angels, Padres, and Giants next. The Miami Marlins are batting .248 on the season, have a .312 OBP, and a .390 slugging percentage. The Miami Marlins’ pitching staff has a 5.56 ERA and a 1.49 WHIP. Kyle Stowers leads the Miami Marlins with 49 hits and 30 RBI, while Xavier Edwards and Eric Wagaman have combined for 83 hits and 23 RBI.

Max Meyer gets the ball for the Miami Marlins, and he is 3-4 with a 4.47 ERA and 59 strikeouts this season. This will be Meyer’s second career game against the Chicago Cubs.

Why the Miami Marlins will win

• The Cubs have lost four of their last five games as favorites against National League opponents following a win.
• The Marlins have won three of their last four games as underdogs following a home loss.
• The Cubs have failed to cover the run line in each of their last six games against National League opponents following a win.
• The Marlins have covered the run line in five of their last six day games following a loss.
• The Cubs have trailed after 3 innings in each of their last six Wednesday games.
• The Marlins have led after 5 innings in five of their last six day games against the Cubs at LoanDepot Park.
• The Marlins have won the first inning in each of their last five Wednesday home games against NL Central opponents.

Why the Chicago Cubs will win

• The Marlins have lost five of their last six day games against National League opponents.
• The Cubs have won five of their last six day games against teams that held a losing record.
• The Cubs have covered the run line in five of their last six day games against teams that held a losing record.
• The Marlins have failed to cover the run line in each of their last three day games against National League opponents.
• The Marlins have trailed after 5 innings in five of their last six day games against National League opponents.
• The Marlins have trailed after 3 innings in four of their last five day games against National League opponents that held a winning record.

Miami Marlins Player Prop Facts

• Jesus Sanchez has hit a home run in two of the Marlins’ last three home games against the Cubs.
• Otto Lopez has recorded at least one RBI in six of his last eight appearances with the Marlins as home underdogs against NL Central opponents.
• Otto Lopez has scored at least one run in seven of his last nine appearances with the Marlins as underdogs against NL Central opponents.
• Otto Lopez has recorded a Single in four of his last five appearances with the Marlins as home underdogs against NL opponents.
• Otto Lopez has recorded at least one hit in 12 of his last 13 home appearances against opponents that held a winning record.
• Kyle Stowers ranks 9th amongst qualified players for Slugging Percentage (.563) this season.

Chicago Cubs Player Prop Facts

• Kyle Tucker has hit a home run in four of his last five appearances in day games against NL teams that held a losing record.
• Ian Happ has recorded an RBI in each of his last five appearances with the Cubs as road favorites against NL East opponents.
• Nico Hoerner has scored at least one run in eight of the Cubs’ last nine games as favorites.
• Ian Happ has recorded at least one Single in each of his last eight road appearances after playing the previous day.
• Dansby Swanson has recorded at least one hit in each of the Cubs’ last 15 road games against NL opponents that held a losing record.
• Justin Turner has recorded a Double in each of his last four appearances with his team as a road favorite against the Marlins.
• Pete Crow-Armstrong ranks 5th in the league in Steals (14) this season.

Marlins vs Cubs Prediction

The Cubs are the better team playing the better baseball, but I’m looking at the over in this spot. Both offenses have had success in this series, and that should continue with the quick turnaround. Horton has allowed 11 hits and six runs in nine innings this season. Meyer has allowed 21 hits and 13 earned runs in his last 16.1 innings, and he’s allowed 18 earned runs in his last 20.1 innings. The Marlins have had a lot of double-digit scoring games over the last couple of weeks, and this could be another with the way both pitchers look. Give me the over on Wednesday afternoon.