Cubs vs White Sox Prediction 5/17/25 MLB Picks Today

In this article, we will formulate a Cubs vs White Sox prediction for this MLB game on Saturday, May 17th at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

Chicago Cubs Betting Preview

The Chicago Cubs are 26-19 this year after they won game one by a score of 13-3 on Friday afternoon. Chicago trailed 2-0 in the first inning, but their offense exploded for 13 runs in the blowout win. The Cubs recorded 15 hits in the game and they were led by Crow-Armstrong, who went 4-5 with one home run and six RBIs in the win. Chicago started Horton, who allowed seven hits and three earned runs over 5.0 innings for the win, while Palencia, Thielbar, Pressly, and Merryweather combined for four scoreless innings in relief. 

Prior to this series, the Cubs won two out of three against the Marlins, but lost two out of three against the Mets before that. Chicago has won three of their last four games, and they are currently first in the NL Central standings. The Chicago pitching staff has a 4.00 ERA with a 1.30 WHIP and a .250 opponent batting average, while their offense has scored 257 runs with a .253 batting average and a .329 on-base percentage this season. Pete Crow-Armstrong has led Chicago with 12 home runs and 36 RBIs, while Seiya Suzuki has added 11 home runs and 37 RBIs this year. The projected starting pitcher for Chicago is Matthew Boyd, who is 3-2 with a 2.78 ERA and a 1.30 WHIP over 45.1 innings pitched this year. 

Chicago White Sox Betting Preview

The Chicago White Sox are 14-31 this season after they were blown out in game one of this series. Chicago jumped out to a 2-0 lead in the first inning, and they added a run in the third, but they were no match for the Cubs’ offense in the loss. The White Sox recorded 11 hits and they committed two errors in the game, while they were led by Vargas, who went 4-4 with two home runs and three RBIs in the loss. Chicago started Smith, who allowed seven hits and one earned run over 5.0 innings for the loss, while four different relievers allowed at least one earned run in the game. 

Prior to this series, the White Sox won two out of three against the Reds and two out of three against the Marlins. Chicago has won three of their last five games, and they are currently last in the AL Central standings. The Chicago pitching staff has a 4.15 ERA with a 1.39 WHIP and a .252 opponent batting average, while the offense has scored 152 runs with a .217 batting average and a .290 on-base percentage this season. Luis Robert has led Chicago with five home runs and 17 RBIs, while Miguel Vargas has added five home runs and 19 RBIs this year. The projected starting pitcher for Chicago is Sean Burke, who is 2-4 with a 4.15 ERA and a 1.41 WHIP over 43.1 innings pitched this season. 

Why the Cubs will beat the White Sox

Total Runs Facts

Chicago Cubs Player Prop Facts

Chicago White Sox Player Prop Facts

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Cubs vs White Sox Prediction 

The Cubs were able to pick up an easy win in game one of this series on Friday afternoon, and they are now 13-10 at home on the year. The White Sox are just 5-19 on the road this season, and they have allowed 20 runs in their last two games. The White Sox are starting Burke, who has allowed one earned run or fewer in three straight starts. The Cubs are going with Boyd, who has allowed two earned runs in four of his last five starts. Boyd has the advantage on the mound, and the Cubs’ offense is much better, so give me the Cubs -1.5 here. 

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