Reds vs Guardians Prediction 5/16/25 MLB Picks Today

In this article, we will formulate a Reds vs Guardians prediction for this MLB game on Friday, May 16th at Great American Ball Park in Cincinnati, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Cincinnati Reds Betting Preview

The Cincinnati Reds are 21-24 this year after they lost two out of three against the White Sox by scores of 1-5, 2-4, and 7-1. In their game three win, Cincinnati scored the first seven runs in the game, and they were able to coast to the easy win. The Reds recorded 12 hits in the game, and they were led by Benson, who went 2-3 with one home run and three RBIs in the win. Cincinnati started Martinez, who allowed two hits and zero earned runs over 7.0 innings for the win, while Rogers allowed two hits and one earned run in relief. 

Prior to that series, the Reds lost two out of three against the Astros and three out of four against the Braves. Cincinnati has lost five of its last seven games, and they are currently fourth in the NL Central standings. The Cincinnati pitching staff has a 3.69 ERA with a 1.18 WHIP and a .222 opponent batting average, while their offense has scored 208 runs with a .239 batting average and a .319 on-base percentage this season. Elly De La Cruz has led Cincinnati with eight home runs and 31 RBIs, while Austin Hays has added five home runs and 15 RBIs this year. The projected starting pitcher for Cincinnati is Brady Singer, who is 4-2 with a 4.97 ERA and a 1.32 WHIP over 41.2 innings pitched this year. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 25-18 this season after they won two out of three against Milwaukee by scores of 5-0, 2-0, and 5-9. In their game three win, Cleveland led 2-1 in the fourth inning, but they allowed the next six runs in the game and fell just short in their comeback attempt. The Guardians recorded seven hits in the game, and they were led by Ramirez, who went 1-3 with one home run and three RBIs in the loss. Cleveland started Williams, who allowed four hits and two earned runs over 5.0 innings, while Herrin, Junis, Cantillo, and Kent all allowed at least one earned run in relief. 

Prior to that series, the Guardians lost two out of three against the Phillies, but did win two out of three against the Nationals before that. Cleveland has lost three of their last five games, and they are currently second in the AL Central standings. The Cleveland pitching staff has a 4.14 ERA with a 1.41 WHIP and a .258 opponent batting average, while the offense has scored 176 runs with a .233 batting average and a .308 on-base percentage this season. Kyle Manzardo has led Cleveland with 10 home runs and 25 RBIs, while Jose Ramirez has added eight home runs and 22 RBIs this year. The projected starting pitcher for Cleveland is Tanner Bibee, who is 3-3 with a 3.80 ERA and a 1.22 WHIP over 45.0 innings pitched this season. 

Why the Guardians will beat the Reds

Total Runs Facts

Cincinnati Reds Player Prop Facts

Cleveland Guardians Player Prop Facts

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Reds vs Guardians Prediction 

Cincinnati was able to avoid the sweep against the White Sox with their win on Thursday afternoon, but they have really struggled over the last few weeks and are just 10-12 at home. Cleveland is 11-10 on the road, and their pitching staff has been great in three of their last four games. The Guardians are starting Bibee, who has allowed two earned runs or fewer in four straight starts. The Reds are starting Singer, who has allowed 11 earned runs and 16 hits over his last 8.1 innings. Take Bibee and the Guardians here. 

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