Reds vs Guardians Prediction 5/17/25 MLB Picks Today

The Cleveland Guardians and the Cincinnati Reds meet Saturday in MLB action from Great American Ballpark. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Reds vs Guardians Prediction.

Starting Pitching Matchup

The Cleveland Guardians will trot out Slade Cecconi for the start here, and Cecconi was 2-7 with a 6.66 ERA and 64 strikeouts last season. In his career, Cecconi is 0-1 with a 4.32 ERA and 10 strikeouts against the Reds. Chase Petty will get the start for Cincinnati here and is 0-2 with a 21.94 ERA and 7 strikeouts this season. This will be Petty’s first career start against the Guardians.


Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to bounce back from a 5-4 series-opening loss at the hands of the Reds on Friday to fall to 25-19 on the year. After this series, the Guardians will head on the road for a series against the Minnesota Twins.

Guardians Drop Back-To-Back Games

Steven Kwan leads the Guardians with 55 hits as part of a .325 batting average and 4 home runs, 9 doubles, and 17 RBIs. Kyle Manzardo has 29 hits with 3 doubles, 2 triples, 10 home runs, and a team-high 25 RBIs this year. Gabriel Arias has 8 doubles but also 40 strikeouts, and Manzardo has a team-high 41 strikeouts so far this season. Arias has also added 4 home runs and 19 RBIs, and Jose Ramirez has chipped in 8 home runs and 22 RBIs.

Why the Cleveland Guardians will win

Cleveland Guardians Player Prop Facts

Cincinnati Reds Recap

The Cincinnati Reds look to build on their win over the Guardians from Friday’s clash to improve to 22-24 on the year. After this series, the Reds will head on the road for a game against the Pittsburgh Pirates.

Reds Win Back-To-Back Outings

Elly De La Cruz has a team-high 45 hits with 8 home runs, 31 RBIs, and 14 stolen bases, while TJ Friedl has 43 hits with 6 doubles and 17 RBIs with 8 stolen bases. Gavin Lux has added 41 hits with a team-high 10 doubles and 19 RBIs, while Spencer Steer has 4 home runs and 12 RBIs, and Matt McLain has added 6 homers, 16 RBIs, and 10 stolen bases as well on the year. Jose Trevino’s also chipped in 10 doubles this season.

Cincinnati Reds Player Prop Facts

Cincinnati Reds Player Prop Facts

Total Runs Facts

Reds vs Guardians Prediction

I’m on the over in this game, easily. You have two questionable at best starting pitching options in Cecconi, who hasn’t started this year and wasn’t good in limited action last year, against Chase Petty. He has been blown up in his two starts so far this season. Add in the hitter-friendly nature of Great American Ballpark, and I just think we’re primed and ready for some runs here. Cleveland’s bullpen hasn’t been as sharp this season, and Cincinnati’s bullpen ERA, in my eyes, which is solid on paper, is unsustainable long term, and I think the over cashes here.

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