Tigers vs Guardians Prediction 5/22/25 MLB Picks Today

The Cleveland Guardians and the Detroit Tigers meet Thursday in MLB action from Comerica Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Tigers vs Guardians Prediction.

Starting Pitching Matchup

The Cleveland Guardians will start Tanner Bibee here and Bibee is 3-4 with a 4.06 ERA and 35 strikeouts this season. In his last five starts against the Tigers, Bibee is 1-2 with a 4.67 ERA and 25 strikeouts. Jack Flaherty will get the start for the Tigers here and is 2-5 with a 4.44 ERA and 56 strikeouts this season. In his last five starts against the Guardians, Flaherty is 2-1 with a 1.11 ERA and 26 strikeouts.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to build on their 5-1 win over the Minnesota Twins from Wednesday’s matchup to improve to 26-22 on the year. After this series, the Guardians will head home for a series against the Dodgers.

Guardians Snap Five-Game Losing Streak

Steven Kwan leads the Guardians with 60 hits as part of a .317 batting average and 4 home runs, 11 doubles and 17 RBIs. Kyle Manzardo has 32 hits with 5 doubles, 2 triples, 10 home runs and a team-high 26 RBIs as well this year. Gabriel Arias has 8 doubles but also 46 strikeouts and Manzardo has 45 strikeouts so far this season. Arias has also added 4 home runs and 20 RBIs and Jose Ramirez has chipped in 9 home runs and 24 RBIs.

Why the Cleveland Guardians will win

• The Guardians have won each of their last four games as underdogs following a road win.
• The Tigers have lost seven of their last eight night games against the Guardians following a win.
• The Guardians have covered the run line in each of their last 10 Thursday night games as road underdogs against AL Central opponents.
• The Tigers have failed to cover the run line in each of their last seven games as favorites.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit at least one home run in three of the Guardians’ last four road games against the Tigers.
• Steven Kwan has recorded at least one Double in three of the Guardians’ last four games against AL opponents that held a winning record.
• Carlos Santana has recorded an RBI in each of the Guardians’ last four games as underdogs.
• Steven Kwan has scored at least one run in each of the Guardians’ last five night games against AL opponents that held a winning record.
• Steven Kwan has recorded at least one Single in each of the Guardians’ last nine road games against AL opponents that held a winning record.
• Jose Ramirez has recorded at least one hit in each of the Guardians’ last 14 games.
• Steven Kwan ranks T4th in the league in Hits (60) this season.

Detroit Tigers Recap

The Detroit Tigers come into this game looking to add on to their 5-1 win over the St. Louis Cardinals last time out to improve to 33-17 on the year. After this series, the Tigers will welcome the San Francisco Giants to town for an interleague set.

Tigers Win 7 Of Their Last 9

Spencer Torkelson has 43 hits along with a .249 batting average including a team-high 12 home runs, 13 doubles and 39 RBIs. Kerry Carpenter also has 10 home runs and 22 RBIs while Riley Greene has 54 hits with 10 doubles, 12 home runs and 34 RBIs but also has a team-high 59 strikeouts as well this season. Dillon Dingler has 4 home runs and 18 RBIs and Zack McKinstry’s added 9 doubles, 3 triples, 2 home runs and 17 RBIs of his own along with 44 hits as well this season. Javier Baez had added 40 hits and 8 doubles as well as 6 home runs and 29 RBIs this season.

Why the Detroit Tigers will win

• The Tigers have won 11 of their last 12 night games against AL Central opponents.
• The Guardians have lost five of their last six games.
• The Tigers have covered the run line in each of their last 12 night games against AL Central opponents.
• The Guardians have failed to cover the run line in each of their last four road games against American League opponents following a win.

Detroit Tigers Player Prop Facts

• Riley Greene has hit a home run in three of the Tigers’ last four games as favorites.
• Kerry Carpenter has recorded at least one RBI in each of his four previous appearances with the Tigers as favorites against the Guardians.
• Jack Flaherty has recorded a win in each of his last four home appearances against AL Central opponents.
• Jack Flaherty has recorded six or more strikeouts in eight of his last nine appearances against AL Central opponents.
• Zach McKinstry has recorded at least one Single in each of his last seven home appearances against opponents that held a winning record.
• Matt Vierling has scored at least one run in each of his last six appearances with the Tigers as home favorites against AL Central opponents.
• Matt Vierling has recorded at least one Double in four of the Tigers’ last five games as favorites against the Guardians.
• Parker Meadows has recorded at least one hit in each of his last 13 appearances in night games.
• Riley Greene ranks T9th in the league in Home Runs (12) this season.

Total Runs Facts

• Each of the Tigers’ last six night games after playing the previous day have gone OVER the total runs line.
• Seven of the Guardians’ last eight night games after playing the previous day have gone UNDER the total runs line.

Tigers vs Guardians Prediction

I’m on the Tigers here. I just haven’t loved the form of Tanner Bibee on the road and Jack Flaherty has been a lot better at home this season as have the Tigers. Flaherty also has had a lot of success going back to last year against the Guardians, and I think this ends up being a win for the Tigers to start the series. Give me Detroit to draw first blood in this one.