Red Sox vs Orioles Prediction 5/22/25 MLB Picks Today

The Baltimore Orioles and the Boston Red Sox meet Thursday in MLB action from Fenway Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Red Sox vs Orioles Prediction.

Starting Pitching Matchup

The Baltimore Orioles will send out Cade Povich for the start here and is 1-3 with a 5.23 ERA and 38 strikeouts this season. In his career, Povich is 0-2 with a 5.28 ERA and 19 strikeouts against the Red Sox. The Boston Red Sox will trot out Lucas Giolito for the start here, and Giolito is 1-1 with a 7.08 ERA and 17 strikeouts this season. In his last five starts against the Orioles, Giolito is 3-2 with a 5.19 ERA and 25 strikeouts.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to build some momentum after salvaging a win from their series against the Milwaukee Brewers to start the week by a final score of 8-4 to improve to 16-32 on the year. After this series, the Orioles will head home for an interleague series against the St. Louis Cardinals.

Orioles Snap Eight-Game Losing Streak

Cedric Mullins has 39 hits so far this season, as well as 9 doubles, 10 home runs, and 31 RBIs with 7 stolen bases and a .236 batting average, while Adley Rutschman has 35 hits with 7 doubles, 5 homers, and 14 RBIs. Ryan Mountcastle has 38 hits with 10 doubles, and Jackson Holliday has 41 hits with 4 doubles, 2 triples, 6 homers, and 19 RBIs. Ryan Mountcastle has 38 hits with 10 doubles, 2 homers, and 14 RBIs, and Gunnar Henderson has a team-high 51 strikeouts as well this season. Ryan O’Hearn also chipped in 41 hits with 6 doubles and 7 home runs with 16 RBIs, and Heston Kjerstad added 4 homers and 15 RBIs.

Why the Baltimore Orioles will win

Baltimore Orioles Player Prop Facts

Boston Red Sox Recap

The Boston Red Sox come into this game looking to bounce back from their 5-1 loss at the hands of the New York Mets on Wednesday to fall to 25-26 this season. After this series, the Red Sox will head on the road for an interleague series against the Milwaukee Brewers.

Red Sox Fail To Complete Sweep Vs. Mets

Alex Bregman leads the Red Sox with 58 hits, including a team-high 17 doubles along with 11 home runs and 35 RBIs, while Rafael Devers has added 54 hits with 14 doubles, 10 home runs and 39 RBIs this season. Trevor Story added 43 hits with 6 home runs, 21 RBIs, and 8 stolen bases, while Jarren Duran has 57 hits with 11 doubles, 6 triples, 3 home runs, 29 RBIs, and a team-high 12 stolen bases. Kristian Campbell added 36 hits with 8 doubles, 5 homers, and 15 RBIs while Wilyer Abreu has 11 home runs with 27 RBIs and 4 stolen bases, and Ceddanne Rafaela has 2 homers, 2 triples, 18 RBIs, and 7 stolen bases this season.

Why the Boston Red Sox will win

Boston Red Sox Player Prop Facts

Total Runs Facts

Red Sox vs Orioles Prediction

I’m on the Red Sox in this one. I get the case to be made for an underdog in some spots, but I’m simply not getting enough plus money to take a shot on Baltimore here. Lucas Giolito is one of my least favorite options in Boston’s rotation, but the Orioles haven’t been able to cash in much against righties as of late, and I think they blow another opportunity here. Give me the Red Sox.

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