Reds vs White Sox Prediction 5/15/25 MLB Picks Today

In this article we will formulate a Reds vs White Sox prediction for this MLB game on Thursday, May 15th at Great American Ball Park in Cincinnati, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Cincinnati Reds Betting Preview

The Cincinnati Reds are 20-24 this year and they have lost the first two games in this series by scores of 1-5 and 2-4. In their game two loss, Cincinnati allowed the first four runs in the game, but they did score twice in the late innings to avoid being shutout. The Reds recorded nine hits in the game and they were led by Hays and Steer, who both had one RBI in the loss. Cincinnati started Lodolo, who allowed seven hits and three earned runs over 5.1 innings for the loss, while Barlow allowed one hit and one earned run over 1.2 relief innings. 

Prior to this series, the Reds lost two out of three against the Astros and three out of four against the Braves. Cincinnati has lost nine of their last eleven games and they are currently fourth in the NL Central standings. The Cincinnati pitching staff has a 3.75 ERA with a 1.19 WHIP and a .224 opponent batting average, while their offense has scored 201 runs with a .236 batting average and a .318 on base percentage this season. Elly De La Cruz has led Cincinnati with seven home runs and 30 RBIs, while Austin Hays has added five home runs and 14 RBIs this year. The projected starting pitcher for Cincinnati is Nick Martinez, who is 1-4 with a 4.23 ERA and a 1.30 WHIP over 44.2 innings pitched this year. 

Chicago White Sox Betting Preview

The Chicago White Sox are 14-29 this season after they won game two by a score of 4-2 on Wednesday night. Chicago jumped out to an early 1-0 lead and they were able to score the first four runs in the game for the win. The White Sox recorded 10 hits in the game and they were led by Robert Jr., Vaughn, Sosa, and Taylor, who all had one RBI in the win. Chicago started Martin, who allowed seven hits and one earned run over 6.2 innings for the win, while Vasil picked up the save. 

Prior to this series, the White Sox won two out of three against the Marlins, but did lose all four against the Royals before that. Chicago has won four of their last five games and they are currently last in the AL Central standings. The Chicago pitching staff has a 3.96 ERA with a 1.36 WHIP and a .245 opponent batting average, while the offense has scored 148 runs with a .216 batting average and a .292 on base percentage this season. Luis Robert has led Chicago with five home runs and 17 RBIs, while Andrew Vaughn has added five home runs and 18 RBIs this year. The projected starting pitcher for Chicago is Bryse Wilson, who is 0-1 with a 4.88 ERA and a 1.73 WHIP over 27.2 innings pitched this season. 

Why the Reds will beat the White Sox

• The White Sox have lost 14 of their last 16 road games following a road win.
• The Reds have won three of their last four day games following a loss.
• The White Sox have failed to cover the run line in five of their last six day games against National League opponents that held a losing record.
• The Reds have covered the run line in three of their last four day games following a loss.
• The White Sox have trailed after 5 innings in five of their last six day games against NL Central opponents that held a losing record.

Total Runs Facts

• Eleven of the Reds’ last 12 day games as favorites have gone UNDER the total runs line.
• Each of the White Sox’s last four games have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Reds’ last seven day games against AL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in nine of the White Sox’s last 10 games as road underdogs against National League opponents.

Cincinnati Reds Player Prop Facts

• Spencer Steer has hit a home run in three of the Reds’ last five games against AL Central opponents that held a losing record.
• Spencer Steer has recorded a Double in five of the Reds’ last six games against the White Sox.
• TJ Friedl has recorded at least one Single in each of his last four appearances in day games against teams that held a losing record.
• TJ Friedl has recorded at least one RBI in five of his last six appearances against AL Central opponents that held a losing record.
• TJ Friedl has recorded at least one hit in each of his last nine appearances in day games against teams that held a losing record.
• Elly De La Cruz has scored at least one run in 10 of the Reds’ last 11 games against AL opponents that held a losing record.

Chicago White Sox Player Prop Facts

• Andrew Vaughn has recorded at least one RBI in six of his last seven appearances in day games against NL teams that held a losing record.
• Andrew Vaughn has recorded a hit in each of the White Sox’s last nine games against NL opponents.
• Luis Robert has scored at least one run in each of his last seven appearances against the Reds after playing the previous day.
• Andrew Benintendi has hit at least one home run in three of his last four appearances against NL Central opponents that held a losing record.
• Andrew Vaughn has recorded a Double in each of the White Sox’s last three road games against NL Central opponents.
• Luis Robert has recorded at least one Single in each of his last five appearances against the Reds after playing the previous day.

Reds vs White Sox Prediction 

Cincinnati comes into this contest looking to avoid a very embarrassing sweep to the White Sox, but they have scored a total of three runs in their last four games. The Reds are 9-12 at home this year, while the White Sox are 5-17 on the road. Chicago has played very well in their last five games, but Wilson has been shaky on the mound. Cincinnati is starting Martinez, who has allowed two earned runs or fewer in three of his last four starts. I like how Martinez has pitched in his last four outings, so I will take the Reds -1.5 here.