Pirates vs Reds Prediction 5/21/25 MLB Picks Today

In this article, we will formulate a Pirates vs Reds prediction for this MLB game on Wednesday, May 21st at PNC Park in Pittsburgh, Pennsylvania. Let’s take a look at the prediction for this MLB matchup. 

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 16-33 this season after they split the first two games in this series by scores of 1-7 and 1-0. In their game two win, Pittsburgh scored in the sixth inning and was able to hang on for the win. The Pirates recorded six hits in the game, and they were led by Reynolds, who went 1-4 with one RBI in the loss. Pittsburgh started Falter, who allowed four hits and zero earned runs over 7.0 innings for the win, while Bednar picked up the save. 

Prior to this series, the Pirates lost all three games against the Phillies and two out of three against the Mets. Pittsburgh has lost four of its last five games, and they are currently last in the NL Central standings. The Pittsburgh pitching staff has a 4.03 ERA with a 1.26 WHIP and a .241 opponent batting average, while their offense has scored 143 runs with a .216 batting average and a .297 on-base percentage this season. Oneil Cruz has led Pittsburgh with eight home runs and 18 RBIs, while Bryan Reynolds has added six home runs and 23 RBIs this year. The projected starting pitcher for Pittsburgh is Andrew Heaney, who is 2-3 with a 3.02 ERA and a 1.14 WHIP over 50.2 innings pitched this season. 

Cincinnati Reds Betting Preview

The Cincinnati Reds are 25-25 this year after they lost game two by a score of 1-0 on Tuesday night. Cincinnati had some chances to score early in the game, but never found a timely hit in the shutout loss. The Reds recorded five hits and they committed one error in the game, while they were led by Friedl, who went 2-4 in the loss. Cincinnati started Martinez, who allowed four hits and one earned run over 6.0 innings for the loss, while Mey and Richardson pitched the final two innings. 

Prior to this series, the Reds swept the Guardians in three games, but lost two out of three against the White Sox before that. Cincinnati has won five of its last six games, and they are currently third in the NL Central standings. The Cincinnati pitching staff has a 3.49 ERA with a 1.16 WHIP and a .221 opponent batting average, while their offense has scored 227 runs with a .243 batting average and a .319 on-base percentage this season. Elly De La Cruz has led Cincinnati with eight home runs and 33 RBIs, while Austin Hays has added six home runs and 19 RBIs this year. The projected starting pitcher for Cincinnati is Brady Singer, who is 5-2 with a 5.01 ERA and a 1.31 WHIP over 46.2 innings pitched this year. 

Why the Pirates will beat the Reds

Total Runs Facts

Pittsburgh Pirates Player Prop Facts

Cincinnati Reds Player Prop Facts

Pirates vs Reds Prediction 

Cincinnati had its winning streak snapped on Tuesday night, but they pitched well in the game, and they have allowed just one run in four straight games. The Reds are 12-13 on the road this year, while the Pirates are 10-14 at home. Pittsburgh has had a very tough season, and their offense is one of the lowest scoring in the MLB, but they got a great start from Falter last night. The Pirates are starting Heaney, who has allowed two earned runs or fewer in three of his last five starts. The Reds are going with Singer, who has allowed 14 earned runs in his last 13.1 innings. Singer has taken a step back recently, and Heaney has been pretty reliable for the Pirates. Take Pittsburgh here. 

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