Twins vs Guardians Prediction 5/21/25 MLB Picks Today

In this article, we will formulate a Twins vs Guardians prediction for this MLB game on Wednesday, May 21st at Target Field in Minneapolis, Minnesota. Let’s take a look at the prediction for this MLB matchup. 

These two teams tried playing game one on Monday night, but play was suspended in the fourth inning with Minnesota up 2-1. They attempted to finish game one and play game two on Tuesday night, but neither of those happened due to the weather. On Wednesday, they will finish game one and play game two, while game three has been postponed to a date in September. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 25-21 this year after they lost all three games against Cincinnati by scores of 4-5, 1-4, and 1-3. In their game three loss, Cleveland had plenty of baserunners, but only managed one run in the seventh inning for the loss. The Guardians recorded nine hits and they committed one error in the game, while they were led by Santana, who had the lone RBI in the game. Cleveland started Ortiz, who allowed six hits and two earned runs over 5.0 innings for the loss, while Gaddis allowed two hits and one earned run in the sixth. 

Prior to that series, the Guardians won two out of three against the Brewers, but dropped two out of three against the Phillies before that. Cleveland has lost four games in a row, and they are currently third in the AL Central standings. The Cleveland pitching staff has a 4.14 ERA with a 1.41 WHIP and a .260 opponent batting average, while the offense has scored 182 runs with a .233 batting average and a .307 on-base percentage this season. Kyle Manzardo has led Cleveland with 10 home runs and 25 RBIs, while Jose Ramirez has added nine home runs and 23 RBIs this year. The projected starting pitcher for Cleveland is Tanner Bibee, who is 3-4 with a 4.06 ERA and a 1.29 WHIP over 51.0 innings pitched this year. 

Minnesota Twins Betting Preview

The Minnesota Twins are 26-21 this season after they won two out of three against Milwaukee by scores of 3-0, 7-0, and 2-5. In their game three loss, Minnesota cut the deficit to 4-2 in the seventh inning, but couldn’t get any closer in the loss. The Twins recorded six hits in the game, and they were led by Lee and Lewis, who both had one RBI in the loss. Minnesota started Matthews, who allowed five hits and four earned runs over 3.0 innings for the loss, while Alcala allowed one earned run in the eighth. 

Prior to that series, the Twins swept the Orioles in three games and swept the Giants in three games. Minnesota has won 13 of its last 14 games, and they are currently second in the AL Central standings. The Minnesota pitching staff has a 3.20 ERA with a 1.14 WHIP and a .228 opponent batting average, while their offense has scored 194 runs with a .242 batting average and a .310 on-base percentage this season. Byron Buxton (IL) has led Minnesota with 10 home runs and 27 RBIs, while Trevor Larnach has added seven home runs and 23 RBIs this year. The projected starting pitcher for Minnesota is Chris Paddack, who is 2-3 with a 4.05 ERA and a 1.18 WHIP over 46.2 innings pitched this season. 

Why the Twins will beat the Guardians

Why the Guardians will beat the Twins

Total Runs Facts

Minnesota Twins Player Prop Facts

Cleveland Guardians Player Prop Facts

Twins vs Guardians Prediction 

Cleveland comes into this series after losing four games in a row, and they have scored one run in each of their last two games. The Guardians are 11-13 on the road this year, while the Twins are 15-6 at home. Minnesota is red hot right now, but they are coming off a loss on Sunday against Milwaukee. The Twins are starting Paddack, who has allowed two earned runs or fewer in four of his last five starts. The Guardians are starting Bibee, who has allowed two earned runs or fewer in four of his last five starts. I know the Twins are hot right now, but I like this pitching matchup with Bibee on the mound. Take the under here. 

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