Orioles vs Nationals Prediction 5/16/25 MLB Picks Today

In this article, we will formulate an Orioles vs Nationals prediction for this MLB game on Friday, May 16th at Camden Yards in Baltimore, Maryland. Let’s take a look at the prediction for this MLB matchup. 

Baltimore Orioles Betting Preview

The Baltimore Orioles are 15-27 this season after they lost all three games against the Twins by scores of 3-6, 6-8, and 0-4. In their game three loss, Baltimore allowed three runs in the third inning, which was enough for the loss, as their offense didn’t do anything. The Orioles recorded six hits in the game, and they were led by O’Hearn, who went 2-4 in the loss. Baltimore started Sugano, who allowed six hits and four earned runs over 6.1 innings for the loss, while Perez and Dominguez combined for 2.2 scoreless innings. 

Prior to that series, the Orioles won two out of three against the Angels, but did lose all three against the Twins before that. Baltimore has lost nine of their last eleven games, and they are currently last in the AL East standings. The Baltimore pitching staff has a 5.34 ERA with a 1.48 WHIP and a .276 opponent batting average, while their offense has scored 156 runs with a .226 batting average and a .295 on-base percentage this season. Cedric Mullins has led Baltimore with eight home runs and 25 RBIs, while Ryan O’Hearn has added seven home runs and 14 RBIs this year. The projected starting pitcher for Baltimore is Cade Povich, who is 1-3 with a 5.55 ERA and a 1.54 WHIP over 35.2 innings pitched this season. 

Washington Nationals Betting Preview

The Washington Nationals are 18-27 this year after they lost three out of four against Atlanta by scores of 3-4, 2-5, 5-4, and 2-5. In their game four loss, Washington allowed the first four runs in the game and came up short in their late rally. The Nationals recorded six hits and they committed one error in the game, while they were led by Abrams, who went 2-4 with one home run and one RBI in the loss. Washington started Williams, who allowed five hits and three earned runs over 4.1 innings for the loss, while Lopez allowed two hits and one earned run over one inning in relief. 

Prior to that series, the Nationals lost all three against the Cardinals and two out of three against the Guardians. Washington has lost eight of their last nine games, and they are currently fourth in the NL East standings. The Washington pitching staff has a 5.37 ERA with a 1.45 WHIP and a .266 opponent batting average, while the offense has scored 183 runs with a .238 batting average and a .308 on-base percentage this season. James Wood has led Washington with 11 home runs and 25 RBIs, while Nathaniel Lowe has added seven home runs and 30 RBIs this year. The projected starting pitcher for Washington is MacKenzie Gore, who is 2-4 with a 3.59 ERA and a 1.16 WHIP over 52.2 innings pitched this year. 

Why the Nationals will beat the Orioles

• The Orioles have lost each of their last five games as home favorites.
• The underdogs have won four of the Orioles’ last five games.
• The Orioles have failed to cover the run line in seven of their last eight games at Oriole Park at Camden Yards.
• The underdogs have covered the run line in each of the Orioles’ last five games at Oriole Park at Camden Yards.
• The Orioles have trailed after 5 innings in each of their last four home games against opponents that held a losing record.
• The Orioles have lost the first inning in three of their last four games as favorites against NL East opponents.
• The Orioles have trailed after 3 innings in seven of their last eight night games against opponents that held a losing record.

Total Runs Facts

• Each of the Nationals’ last 10 games against AL East opponents have gone UNDER the total runs line.
• Each of the Orioles’ last six home games against National League opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Orioles’ last six games as home favorites against NL East opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Nationals’ last eight games at Oriole Park at Camden Yards.

Baltimore Orioles Player Prop Facts

• Gunnar Henderson has hit a home run in two of the Orioles’ last three games against opponents that held a losing record.
• Ramon Laureano has recorded a Double in each of his last three appearances against the Nationals.
• Ramon Laureano has scored at least one run in five of his last six appearances against opponents that held a losing record.
• Ramon Urias has recorded a Single in seven of his last eight home appearances against NL East opponents.
• Ramon Laureano has recorded at least one hit in each of his last 12 appearances in night games against NL teams that held a losing record.
• Colton Cowser has recorded at least one RBI in five of his last six appearances with the Orioles as favorites against NL East opponents.

Washington Nationals Player Prop Facts

• Jacob Young has recorded at least one Double in three of his four previous appearances in night games against AL East teams that held a losing record.
• CJ Abrams has hit a home run in three of his last four road appearances against opponents that held a losing record.
• Josh Bell has recorded at least one RBI in each of his last four appearances against the Orioles after playing the previous day.
• Josh Bell has scored a run in five of his last six appearances against the Orioles after playing the previous day.
• MacKenzie Gore has recorded seven or more strikeouts in six of his last seven appearances.
• Keibert Ruiz has recorded at least one Single in each of his last six appearances with the Nationals as road underdogs against AL opponents.
• Josh Bell has recorded at least one hit in each of his last eight appearances against the Orioles after playing the previous day.

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Orioles vs Nationals Prediction 

Both of these teams come into this series really struggling over the last two weeks, but Baltimore will be at home for this matchup. The Orioles are 8-12 at home this year, while the Nationals are 8-15 on the road. Washington has scored two runs or fewer in three of their last five games, and they will go against Povich, who has allowed five earned runs or more in two of his last four starts. Baltimore has been one of the lowest-scoring teams in the MLB this year, and they are facing Gore, who has allowed 4, 1, and 3 earned runs in his last three outings. I don’t like the direction of either team in this matchup, but I will take Gore over Povich. Take the Nats here.